Kiele Sanchez ("Married to the Kellys") is joining the cast of the show, which revolves around four sisters (Sanchez, Jennifer Esposito, Laura Breckenridge and Lizzy Caplan) in New York. She replaces former "Just Shoot Me" star Laura San Giacomo, who starred in the pilot, according to The Hollywood Reporter.

WB Entertainment president David Janollari said at the network's upfronts in May that San Giacomo left the show due to the standard "creative reasons." If nothing else, the character, who's supposed to be the oldest of the four siblings, will now be a little bit younger: San Giacomo is 42, and while a fairly time-consuming search failed to turn up Sanchez's birthdate, she's primarily played characters in their 20s.

Sanchez's casting in "Related" means she's departing NBC's midseason comedy "Four Kings." She co-starred in the pilot as the girlfriend of Josh Cooke's ("Committed") character, one of four lifelong friends who share a New York apartment. The part will now become a guest role.

In addition to "Married to the Kellys," Sanchez also starred in the short-lived ABC series "That Was Then" in fall 2002. Her credits also include the Farrelly brothers feature "Stuck on You."